Interleukin-17 Inhibition in a Patient With Psoriasis and Concurrent Vitiligo

Autor:	Jacquelyn R. Sink, Kimberly L. Katz, Katherine Rupley, Alice B. Gottlieb, Adele Shuley
Rok vydání:	2018
Předmět:	medicine.medical_specialty integumentary system business.industry Dermatology Vitiligo medicine.disease Systemic therapy Ixekizumab Rheumatology Psoriasis Medicine In patient Interleukin 17 skin and connective tissue diseases business
Zdroj:	Journal of Psoriasis and Psoriatic Arthritis. 3:126-130
ISSN:	2475-5311 2475-5303
DOI:	10.1177/2475530318788943
Popis:	Background: Psoriasis and vitiligo are 2 autoimmune conditions that can occur concurrently in patients. At present, no single systemic therapy has been identified to be effective in treating both the conditions. Observations: Recent advances in our understanding of the T helper (Th) 17 subset of Th cells suggests that interleukin (IL)-17 may play a key role in the pathogenesis of both vitiligo and psoriasis. We report a case of anatomically superimposed psoriatic plaques and vitiligo for which treatment with ixekizumab leads to resolution of psoriasis but did not improve the patient’s vitiligo. Conclusion: While IL-17 is highly effective in the treatment of psoriasis, it does not seem to be an effective treatment for vitiligo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::937f6482e8f9f9caef88a3f12b2f0079 https://doi.org/10.1177/2475530318788943 Zobrazit plný text záznamu