ChemInform Abstract: Synthesis of C2 Alkynylated Purines, a New Family of Potent Inhibitors of Cyclin-Dependent Kinases

Autor:	Laurent Meijer, Odile Ludwig, Michel Legraverend, Emile Bisagni, Sébastien Leclerc
Rok vydání:	2010
Předmět:	biology Biochemistry Cyclin-dependent kinase Kinase Chemistry biology.protein Purine derivative General Medicine Cell cycle Purine metabolism IC50
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199830175
Popis:	The synthesis of a new family of inhibitors of the cell cycle regulating cyclin-dependent kinases (CDK's) is reported. These compounds, related to the purines olomoucine and roscovitine, are characterised by the presence of alkynylated side chains at C2. They inhibit CDK's with IC50's in the 200 nM range.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::937849d6dc01d50733385099adc36270 https://doi.org/10.1002/chin.199830175 Zobrazit plný text záznamu Plný text