2-Substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinones as potential anti-inflammatory agents

Autor:	Devashish Mukherjee, BK Goel, J. N. Sinha, Ritu Tyagi, Tilak Ram, Ekta Bansal, Ashok Kumar
Rok vydání:	1999
Předmět:	Pharmacology medicine.drug_class Organic Chemistry Biological activity General Medicine Chemical synthesis Medicinal chemistry Anti-inflammatory chemistry.chemical_compound chemistry Oral administration Drug Discovery medicine Anthranilic acid Phenylbutazone Potency ED50 medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 34:265-269
ISSN:	0223-5234
Popis:	New anthranilic acid derivatives, 2-substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinone, were synthesized and evaluated for their anti-inflammatory activity against carrageenan-induced oedema in albino rats. The most active member of the series, 3-(4-bromo-2-carboxyphenyl)-2-(2-fluorophenyl)-5-methyl-4-thiazolidinone 6 was compared with phenylbutazone for its relative anti-inflammatory potency and ulcerogenic liability. ED50, cardiovascular and central nervous system effects of 6 were also studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::935f2793b5a24e1adf74ecfde51aeb7e https://doi.org/10.1016/s0223-5234(99)80060-9 Zobrazit plný text záznamu Full Text from ScienceDirect