Asymmetric oxidation of 2-(arylsulfenyl)pyrroles

Autor:	Alison Thompson, H. Martin Gillis, José Ramon Garabatos-Perera
Rok vydání:	2008
Předmět:	Chemistry Organic Chemistry Electronic effect Substrate (chemistry) Organic chemistry General Chemistry Medicinal chemistry Catalysis
Zdroj:	Canadian Journal of Chemistry. 86:676-681
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v08-054
Popis:	The asymmetric oxidation of prochiral 2-(arylsulfenyl)pyrroles has been investigated. A marked electronic effect within the substrate significantly influenced the degree of enantioselectivity obtained, with very high enantio selectivity being obtained for 5-(nitrobenzensulfenyl)pyrrole-2-carboxaldehydes using Ti(i-PrO)4/(+)-(R,R)-DET/H2O/CHP. This result bodes well for optimizing the asymmetric oxidation of other diaryl sulfides, substrates that have previously given only low enantiomeric excesses.Key words: asymmetric oxidation, sulfide, sulfoxide, pyrrole.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::931740a641147e84c233890126c3b35f https://doi.org/10.1139/v08-054 Zobrazit plný text záznamu Plný text ve formátu PDF