| Autor: |
Jordi Salas-Salvadó, Sujatha Rajaram, Joan Sabaté, Torben Hansen, Yoriko Heianza, Miguel Ángel Martínez-González, Wim H. M. Saris, Matti Uusitupa, Montserrat Cofán, Jörg Hager, Alena Stancacova, Jaakko Tuomilehto, Meng Gao, Dianjianyi Sun, Wenjie Ma, J. Alfredo Martínez, Jaana Lindström, Peter Arner, Liana C Del Gobbo, Markku Laakso, Thorkild I. A. Sørensen, Lu Qi, Jean-Michel Oppert, Tao Huang, Arne Astrup, Oluf Pedersen, Mathilde Svendstrup, Jan Polak, Dolores Corella, Dominique Langin, Gabby B. Hul, Zhe Fang, Vanessa D. de Mello, Christopher D. Gardner, Emilio Ros |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3260786 |
| Popis: |
Background: The transcription factor 7-like 2 gene (TCF7L2) is the strongest locus associated by the variant rs7903146 with type 2 diabetes (T2D) identified to date. Whether diet/lifestyle intervention modifies genetic effect of TCF7L2 variant on glucose homeostasis and adiposity is still controversial. Objective: To quantify the modification effects of the diet/lifestyle interventions on genetic association of TCF7L2 variant rs7903146 with glycemic control and adiposity changes in randomized controlled trials (RCTs). Design A large collaborative analysis of individual-participant data from seven RCTs. Setting RCTs conducted in adults reporting changes in glycemic traits, body weight, or waist circumference by TCF7L2 rs7903146 after dietary/lifestyle-based interventions. Gene-treatment interaction models were fitted to individual participant data from all studies, using allele dose coding for genetic effects and a common set of covariates. Results: We included seven eligible RCTs for the joint analysis (n=4,114 participants). Overall, a significant interaction between TCF7L2 rs7903146 and diet/lifestyle interventions on decrease in fasting glucose was observed. Compared with control, diet/lifestyle interventions reduced fasting glucose by -0.17 (95% CI, -0.32 to -0.02) mmol/L (test for heterogeneity: I2=45.1%, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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