Nitazoxanide Cocrystals in Combination with Succinic, Glutaric, and 2,5-Dihydroxybenzoic Acid

Autor:	Jesús Rivera-Islas, Hugo Morales-Rojas, Herbert Höpfl, Brenda C. Félix-Sonda, Dea Herrera-Ruiz
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Carboxylic acid Synthon Supramolecular chemistry Infrared spectroscopy General Chemistry Crystal structure Glutaric acid Condensed Matter Physics Cocrystal chemistry.chemical_compound Crystallography chemistry Succinic acid General Materials Science
Zdroj:	Crystal Growth & Design. 14:1086-1102
ISSN:	1528-7505 1528-7483
Popis:	Combination of nitazoxanide (NTZ) with a total of 32 cocrystal formers gave cocrystals with succinic acid (NTZ-SUC, 2:1) and glutaric acid (NTZ-GLU, 1:1). Additionally, 2,5-dihydroxybenzoic acid provided a cocrystal solvate with acetonitrile (NTZ-25DHBA-CH3CN, 1:1:1). All solid phases were characterized by X-ray powder diffraction analysis, IR spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and single-crystal X-ray diffraction analysis. Single-crystal X-ray crystallography revealed that NTZ and the carboxylic acid cocrystal formers were linked in all three cocrystals through the same supramolecular heterodimeric synthon, C(N)NH···HOOC. Despite having different stoichiometries, the crystal structures of NTZ-SUC and NTZ-GLU showed similarities in the supramolecular organization, both containing two-dimensional layers formed by NTZ molecules, which were further interconnected by single (NTZ-SUC) and homodimeric entities (NTZ-GLU) of the cocrystal former. Basic physical stability ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::927b3d5d61e1614513473fdf6f57c6d1 https://doi.org/10.1021/cg4015916 Zobrazit plný text záznamu