Implantation and early pregnancy: Endometrial Th2 cytokine expression throughout the menstrual cycle and early pregnancy
| Autor: | D.J. Tollerud, J.A. DeLoia, Gregory J. Naus, Joel S. Krasnow |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Pregnancy Stromal cell media_common.quotation_subject medicine.medical_treatment Rehabilitation Obstetrics and Gynecology Interleukin Biology Endometrium medicine.disease medicine.anatomical_structure Endocrinology Cytokine Reproductive Medicine Internal medicine medicine biology.protein Cytokine secretion Interleukin 6 Menstrual cycle media_common |
| Zdroj: | Human Reproduction. 11:1747-1754 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/oxfordjournals.humrep.a019480 |
| Popis: | Embryonic implantation and maintenance of pregnancy is influenced by the maternal immunological response. Type 2 T-helper (Th2) cells secrete interleukins 4, 5, 6 and 10 and are associated with suppression of cell-mediated immunity. Temporal changes in the expression of these cytokines were detectable by immunohistochemistry throughout the menstrual cycle. In pregnancy, 10-fold or greater increases in interleukin 6 and 10 secretion were detectable by enzyme-linked immunoassay compared with the non-pregnant state. The pattern of expression of Th2 cytokines suggests that progesterone may influence endometrial cytokine secretion. During pregnancy, Th2 expression paralleled that of vimentin, a stromal cell marker, suggesting that these cells may be a principal source of these cytokines in the gravid uterus. Increased secretion of Th2 cytokines may be a mechanism of suppressing cell-mediated immunity in the endometrium, which may in turn enhance embryonic implantation and maintenance of pregnancy. |
| Databáze: | OpenAIRE |
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