Evaluation of anticonvulsant activity of angiotensin receptor antagonists in an animal model
| Autor: | Asha D Jadhav, Anand S. Kale, Rakesh R. Jadhav, Prakashchandra Rambhau Gade, Sudhir L. Padwal, Swapnil S. Jadhav |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Basic & Clinical Pharmacology. 10:29 |
| ISSN: | 2279-0780 2319-2003 |
| DOI: | 10.18203/2319-2003.ijbcp20205534 |
| Popis: | Background: Epilepsy is common chronic disorder in clinical practice and there was some studies which shows brain renin angiotensin system may be involved in upregulation of seizures hence present study was planned to investigate whether angiotensin II AT1 receptor antagonists possess anticonvulsant activity in experimental animals.Methods: The anticonvulsant activity of angiotensin receptor antagonists, losartan (50 mg/kg), telmisartan (30 mg/kg) and candesartan (20 mg/kg), were administered intraperitoneally to the mice and evaluated by using maximum electroshock (MES) and pentylenetetrazol induced seizures (PTZ) seizure methods. The standard was taken as phenytoin for MES and diazepam for PTZ method. Motor impairment of performance was assessed by the inverted screen test and spontaneous motor activity with digital actophotometer.Results: Losartan demonstrated the anticonvulsant efficacy in MES and PTZ models. Telmisartan and candesartan have anticonvulsant activity in MES induced seizures, but did not show protection against pentylenetetrazol induced seizures. Losartan at dose 50 mg/kg prolonged the mean latency to convulsion (p |
| Databáze: | OpenAIRE |
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