Bioactive alkaloids from the Red Sea marine Verongid sponge Pseudoceratina arabica

Autor:	Mansour I. Sulaiman, Alaa Khedr, Lamiaa A. Shaala, Khalid A. El Sayed, Jihan M. Badr, Diaa T. A. Youssef
Rok vydání:	2015
Předmět:	biology Stereochemistry Chemistry Organic Chemistry Moderate activity biology.organism_classification Biochemistry HeLa Sponge Drug Discovery Ic50 values Pseudoceratina arabica Spectral data Two-dimensional nuclear magnetic resonance spectroscopy IC50
Zdroj:	Tetrahedron. 71:7837-7841
ISSN:	0040-4020
DOI:	10.1016/j.tet.2015.08.024
Popis:	Three new dibrominated alkaloids, ceratinines F–H (2–4), together with the known compounds molokia'iamine (1), psammaplysin A (5), ceratinamide A (6), 19-hydroxyceratinamide A (7), psammaplysin E (8) and ceratinophenol A (9) were isolated from a new collection of the Red Sea marine sponge Pseudoceratina arabica. The structures of the isolated compounds were assigned by different spectral data including 1D and 2D NMR and HRMS. The compounds were evaluated for their antimigratory activity against the highly metastatic human breast cancer cell line MDA-MB-231 as well as for their antiproliferative activity against HeLa cells. Compound 8 showed potent antimigratory activity with IC50 value of 0.31 μM, while 9 displayed moderate activity with IC50 of 10.4 μM. In addition, compounds 4 and 8 showed potent antiproliferative activities against HeLa cells with IC50 values of 2.56 and 2.19 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::90fe9e2c8464e655dd09b8b814173326 https://doi.org/10.1016/j.tet.2015.08.024 Zobrazit plný text záznamu Full Text from ScienceDirect