Cytotoxic abietane-derivative diterpenoids of Salvia lachnostachys

Autor: Marcos José Salvador, Cristhian Santos Oliveira, João E. de Carvalho, Maria ÿlida A. Stefanello, ÿlide P. Santos, Andersson Barison
Rok vydání: 2016
Předmět:
Zdroj: Phytochemistry Letters. 17:140-143
ISSN: 1874-3900
DOI: 10.1016/j.phytol.2016.07.005
Popis: A bioassay-guided fractionation of Salvia lachnostachys Benth leaf extract led to the isolation of three known diterpenes, namely fruticuline A (1), fruticuline B (2) and 7,20-dihydrofruticuline A (3), together with two new compounds, 4 and 5. The structures were mainly elucidated by 1D and 2D NMR spectroscopy and HRESIMS. The cytotoxic activity of the crude ethanol extract, the semi-purified fractions (A-E) and compounds 1, 2 and 4 were evaluated against seven human cancer cell lines and the normal cell line HaCat. The ethanol extract showed activity against all tested cell lines (GI50 25.0⿿44.0 μg/mL). Among the fractions, the greatest activity was exhibited by fraction A (eluted with hexane), which inhibited the growth of all tested cell lines with GI50 of 3.9⿿19.5 μg/mL. Compounds 1 and 4 were the most active, inhibiting the growth of U251, MCF-7, NCI-ADR/RES, 786.0, NCI-H460, PC-3, OVCAR-03 and HaCat cell lines with GI50
Databáze: OpenAIRE
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