Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue

Autor:	L. A. Stavrova, E. V. Simanina, A. V. Chaikovskii, G. N. Zyuz’kov, M. G. Danilets, V. V. Zhdanov, V I Agafonov, L. A. Miroshnichenko, T Yu Polyakova
Rok vydání:	2021
Předmět:	Cell signaling biology Regeneration (biology) Nervous tissue Subventricular zone General Medicine General Biochemistry Genetics and Molecular Biology Neural stem cell Cell biology medicine.anatomical_structure nervous system biology.protein medicine Neuroglia Progenitor cell Neurotrophin
Zdroj:	Bulletin of Experimental Biology and Medicine. 171:333-337
ISSN:	1573-8221 0007-4888
DOI:	10.1007/s10517-021-05222-3
Popis:	We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling molecules in mitotic activity and specialization of multipotent neural stem cells was shown. It was found that JNK and p53 do not participate in the regulation of committed neuronal progenitor cells (clonogenic PSA-NCAM+ cells). A dependence of neurotrophic growth factors in individual populations of neuroglia on activity of these protein kinase and transcription factor was revealed. The role of JNK and p53 in astrocytes consists in stimulation of their secretion, and in microglial cells, on the contrary, in its inhibition. The secretory neurotrophic function of oligodendrogliocytes is not associated with JNK and p53 activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8ff7f48e826c2400fb28358c64ff57db https://doi.org/10.1007/s10517-021-05222-3 Zobrazit plný text záznamu Full text from SpringerLink