ChemInform Abstract: Synthesis of Pyrryl Aryl Sulfones Targeted at the HIV-1 Reverse Transcriptase

Autor:	P. La Colla, D. Musu, Silvio Massa, Giorgio Stefancich, E. Pagnozzi, Marino Artico, Elisabetta Pinna, F. Scintu, Romano Silvestri, E. Tinti
Rok vydání:	2010
Předmět:	Aryl Human immunodeficiency virus (HIV) General Medicine medicine.disease_cause Combinatorial chemistry Reverse transcriptase In vitro Pyrrole derivatives Sulfone chemistry.chemical_compound chemistry medicine Cytotoxicity Lead compound
Zdroj:	ChemInform. 26
ISSN:	0931-7597
Popis:	Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Some structure-activity relationships are discussed also in comparison with the known NPPS (2-nitrophenyl phenyl sulfone).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8feec2ddf8812c9b56269ac2d3227985 https://doi.org/10.1002/chin.199532152 Zobrazit plný text záznamu Plný text