Autor: |
P. La Colla, D. Musu, Silvio Massa, Giorgio Stefancich, E. Pagnozzi, Marino Artico, Elisabetta Pinna, F. Scintu, Romano Silvestri, E. Tinti |
Rok vydání: |
2010 |
Předmět: |
|
Zdroj: |
ChemInform. 26 |
ISSN: |
0931-7597 |
Popis: |
Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Some structure-activity relationships are discussed also in comparison with the known NPPS (2-nitrophenyl phenyl sulfone). |
Databáze: |
OpenAIRE |
Externí odkaz: |
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