Effect of Superior Cervical Ganglionectomy on 24-h Variations in Hormone Secretion from the Anterior Hypophysis and in Hypothalamic Monoamine Turnover During the Preclinical Phase of Freund's Adjuvant Arthritis in Rats
| Autor: | Ana I. Esquifino, D. P. Cardinali, David Pazo, Rodolfo A. Cutrera, Patricia O. Castrillón |
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| Rok vydání: | 2001 |
| Předmět: |
endocrine system
Pituitary gland medicine.medical_specialty Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Adrenocorticotropic hormone Prolactin Cellular and Molecular Neuroscience Endocrinology medicine.anatomical_structure Hypothalamus Freund's adjuvant Internal medicine Medicine Serotonin Ganglionectomy business Luteinizing hormone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Neuroendocrinology. 13:288-295 |
| ISSN: | 0953-8194 |
| DOI: | 10.1046/j.1365-2826.2001.00627.x |
| Popis: | The effect of superior cervical ganglionectomy (SCGx) on 24-h rhythms of circulating adrenocorticotropic hormone (ACTH), growth hormone (GH), prolactin and luteinizing hormone (LH) and of hypothalamic noradrenaline content and dopamine and serotonin turnover, was assessed in rats 3 days after administering Freund's complete adjuvant. In sham-operated rats, Freund's adjuvant injection increased serum ACTH without affecting its diurnal rhythmicity. SCGx, performed 10 days earlier, suppressed 24-h rhythmicity and augmented mean values of circulating ACTH. A depressive effect of immunization on GH release was found in both sham-operated and SCGx rats. GH concentrations did not exhibit diurnal rhythmicity and decreased after immunization. Time-of-day-related changes in serum prolactin were significant for all examined groups, except for SCGx-immunized rats. Freund's adjuvant administration augmented prolactin secretion. Daily changes in serum LH concentration and a decrease after immunization were found in both sham-operated and SCGx rats. SCGx: (i) counteracted inhibition of daily variations of noradrenaline content in medial hypothalamus of Freund's adjuvant-injected rats; (ii) decreased anterior hypothalamic dopamine turnover and augmented it in the medial hypothalamus; (iii) lowered amplitude of serotonin turnover rhythm in medial hypothalamus. The data indicate that several early changes in levels and 24-h rhythms of circulating ACTH and prolactin, and in hypothalamic noradrenaline content and dopamine and serotonin turnover, were modified by a previous SCGx in Freund's adjuvant-injected rats. |
| Databáze: | OpenAIRE |
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