Stereoselective Synthesis of Hexahydroimidazo[1,2-a]quinolines via SN2-Type Ring-Opening Hydroarylation–Hydroamination Cascade Cyclization of Activated Aziridines with N-Propargylanilines

Autor:	Navya Chauhan, Manas K. Ghorai, Aditya Bhattacharyya, Sajan Pradhan, Chandan Kumar Shahi
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Stereochemistry Organic Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry 0104 chemical sciences Cascade SN2 reaction Stereoselectivity Hydroamination Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 22:7903-7908
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.0c02801
Popis:	A novel synthetic approach for the construction of 1,2,3,3a,4,5-hexahydroimidazo[1,2-a]quinolines in good yields (up to 75%) with excellent stereoselectivity (dr up to 94:6, ee up to >99%) under on...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8fa5ed3b7f5741c4320ce4fab97d8426 https://doi.org/10.1021/acs.orglett.0c02801 Zobrazit plný text záznamu