Choline Acetyltransferase Positive Neurons in the Laboratory Shrew (Suncus murinus) Brain: Coexistence of ChAT/5-HT (Raphe dorsalis) and ChAT/TH (Locus ceruleus)
| Autor: | Genzoh Isomura, Terumi Takeuchi, Mineo Iwasa, Nobuyuki Karasawa, Keiki Yamada |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Histology biology Raphe Physiology Locus Ceruleus Cell Biology Striatum Suncus biology.organism_classification Biochemistry Choline acetyltransferase Pathology and Forensic Medicine medicine.anatomical_structure Endocrinology nervous system Internal medicine mental disorders medicine Tegmentum Cholinergic neuron Nucleus health care economics and organizations |
| Zdroj: | ACTA HISTOCHEMICA ET CYTOCHEMICA. 36:399-407 |
| ISSN: | 1347-5800 0044-5991 |
| DOI: | 10.1267/ahc.36.399 |
| Popis: | We determined the distribution pattern of cholinergic neurons in laboratory shrews (Suncus murinus) based on comparative morphology by an immunohistochemical method using an anticholine acetyltransferase (ChAT) antibody. ChAT-positive neurons were observed in the striatum, magnocellular nucleus and basal nucleus, pontine tegmentum and cranial nerve motor nuclei (IV, V, VII, X and XII). Specific findings were as follows: many ChAT-positive neurons were observed in the locus ceruleus (LC) and raphe dorsalis (RD), and the colocalization of ChAT-positive neurons and tyrosine hydroxylase in the LC and that of ChAT-positive neurons and serotonin in the RD were clarified. On the other hand, in the rat brain, ChAT-positive neurons were present in the central amygdaloid nucleus; however, this was not observed in the brains of laboratory shrews. Laboratory shrews are among the most primitive mammalian species and have a different distribution pattern of aminergic neurons, other than cholinergic neurons, from that in rats. A unique distribution pattern of ChAT-positive neurons in the laboratory shrew brain was thus noted. |
| Databáze: | OpenAIRE |
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