2,4-Disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones: synthetic approaches to and consequent chemical modification

Autor:	Volodymyr M. Kotliar, Olexandre V. Buravov, Andrey O. Doroshenko, Dmytro O. Tarasenko, Oleksii O. Kolomoitsev
Rok vydání:	2020
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Biological property Chemical modification General Chemistry 010402 general chemistry Thiazole 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	Monatshefte für Chemie - Chemical Monthly. 151:765-772
ISSN:	1434-4475 0026-9247
Popis:	Arylideneketones are commonly considered as convenient starting materials for obtaining compounds of potential pharmaceutical interest. Heterocyclic α,β-unsaturated representatives of this series possess chemical and biological properties worth study in details. Particularly, substituted thiazole cycle, incorporated into such a system, allows obtaining of new biologically active products suitable to their consequent chemical modification. In this communication we focus attention on 2,4-disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones on the background of 2,4-dihalogen-5-formylthiazole, several relevant methods of their synthesis and prospective directions of further chemical modification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e740e1882917a6dfd5b1ea5436f9765 https://doi.org/10.1007/s00706-020-02612-7 Zobrazit plný text záznamu Full text from SpringerLink