Foxp3-specific deletion of CREB induces ST-2+ regulatory T-cells with enhanced type 2 response resulting in lupus pathology

Autor: Tenbrock, Klaus, Ohl, Kim, Subramanyam, Sudheendra Hebbar, Clarner, Tim, Scheld, Miriam, Verjans, Eva, Böll, Svenja, Costa, Ivan, Huehn, Jochen, Bopp, Tobias, Lambrecht, Bart, Zenke, Martin, Wagner, Norbert
Jazyk: angličtina
Rok vydání: 2022
Předmět:
DOI: 10.3205/22dgrh050
Popis: Introduction: Regulatory T cells (Tregs) are gatekeepers of immune homeostasis and characterized by expression of Foxp3, which maintains Treg identity. The transcriptional activator CREB was previously shown to stabilize Foxp3 expression in vitro. Methods: To elucidate the function of CREB in regulatory [for full text, please go to the a.m. URL]
Databáze: OpenAIRE