A Practical Method for the Removal of Ruthenium Byproducts by Supercritical Fluid Extraction

Autor:	Fabrice Gallou, Steve T. Horhota, Said Saim, David Joseph Bochniak, and Nathan K. Yee, Koenig Kenneth J, Chris H. Senanayake
Rok vydání:	2006
Předmět:	inorganic chemicals Chemical engineering Chemistry Organic Chemistry Metal impurities Supercritical fluid extraction Salt metathesis reaction Organic chemistry chemistry.chemical_element Ruthenium catalyst Physical and Theoretical Chemistry Supercritical fluid Ruthenium
Zdroj:	Organic Process Research & Development. 10:937-940
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op0601114
Popis:	Supercritical CO2 was used to remove ruthenium catalyst and its derived by-products from a crude ring-closing metathesis reaction. The method was implemented in a semi-continuous fashion and allowed for efficient removal of the toxic metal impurities to meet the specifications for the final drug substance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8e0c0c3f96375f4b364fa82738c0b4b5 https://doi.org/10.1021/op0601114 Zobrazit plný text záznamu