The Transsulfuration Pathway Makes, the Tumor Takes
| Autor: | Ross A. Weber, Kıvanç Birsoy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Methionine Physiology Chemistry Cell Biology Transsulfuration pathway Methylation Limiting Cysteine synthesis 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Biochemistry Cancer cell Molecular Biology 030217 neurology & neurosurgery Cysteine |
| Zdroj: | Cell Metabolism. 30:845-846 |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2019.10.009 |
| Popis: | Cells can take up cysteine or synthesize it de novo from methionine, but synthesis alone does not meet the high demands of cancer cells to proliferate. In this issue, Zhu et al. (2019) identify the SAH:SAM ratio, indicative of the cellular methylation state, as limiting for effective cysteine synthesis and the growth of some tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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