Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN®
| Autor: | Joel R. Huff, Mary Beth Young, Craig A. Coburn, Hungate Randall W, Richard C.A. Isaacs, Joseph P. Vacca |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
Protease biology medicine.medical_treatment Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry In vitro Enzyme inhibition Enzyme chemistry HIV-1 protease Drug Discovery medicine biology.protein Molecular Medicine Whole cell Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:1937-1940 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(96)00345-9 |
| Popis: | A series of analogs of CRIXIVAN® containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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