ChemInform Abstract: A Synthesis of (.+-.)-Demethoxydaunomycinone
| Autor: | Kathryn Carr, James K. Sutherland, Khairuzzaman B. Mullah, Neil A. Greener, Fiona M. Somerville |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | ChemInform. 23 |
| ISSN: | 0931-7597 |
| DOI: | 10.1002/chin.199249280 |
| Popis: | 2-Acetyl-1,4-dihydroxyanthracene-9,10-dione 1 is converted into (±)-demethoxydaunomycinone by substitution with 3,3-dimethoxy-1-nitrobutan-2-one, aldol cyclisation, reduction and hydrolysis. The chiral inductions at C-10 realised on cyclisation of 5 and 8 are reported and the predominant chirality established. |
| Databáze: | OpenAIRE |
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