Seeds of Centranthus ruber and Valeriana officinalis Contain Conjugated Linolenic Acids with Reported Antitumor Effects
| Autor: | Ikumi Sato, Nobuhiro Shiratani, Tetsu Kataoka, Kayoko Kita, Toshihide Suzuki, Yasushi Endo, Taro Honma, Tsutomu Takayanagi, Yuki Banno, Ryo Kimura |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences Valerianaceae Valeriana officinalis biology 030309 nutrition & dietetics Chemistry General Chemical Engineering food and beverages Fatty acid 04 agricultural and veterinary sciences General Medicine General Chemistry biology.organism_classification 040401 food science 03 medical and health sciences Hydrolysis 0404 agricultural biotechnology Glycolipid Officinalis biology.protein Food science Lipase Centranthus ruber |
| Zdroj: | Journal of Oleo Science. 68:481-491 |
| ISSN: | 1347-3352 1345-8957 |
| Popis: | Conjugated linolenic acids (CLNs) are naturally occurring fatty acids that are believed to have anticancer properties. In this study, we examined various plant seeds from herbs to discover seed oils containing CLNs. The ultraviolet spectra of total lipids from these seeds were measured. An absorption maximum around 270 nm was observed in seed oils belonging to the Valerianaceae family (Centranthus ruber and Valeriana officinalis). When the fatty acid compositions of these seed oils were measured, CLNs were detected. By silica column chromatography, neutral lipids (NLs), glycolipids, and phospholipids were eluted from seed oils of C. ruber and V. officinalis. Then, fatty acid compositions of these fractions were measured. This revealed that most of the CLNs in these seed oils existed in the NL fraction. When the NL fractions of these seed oils were reacted with lipase, CLNs showed good sensitivity to lipase hydrolysis. This suggested that the CLNs in the seed oils of C. ruber and V. officinalis existed predominantly at the sn-1,3 position of triacylglycerol and less at the sn-2 position. These results suggested that the CLNs from the seed oils of C. ruber and V. officinalis could easily be taken up by cancer cells as free fatty acids and had good potential as antitumor substances. |
| Databáze: | OpenAIRE |
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