Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs
| Autor: | Begoña Lainez, Vincent P. Schulz, Eric D. Baum, Patrick G. Gallagher, Sang Taek Kim, Jin-Young Choi, Joe Craft, Jennifer Setlur, David E. Karas |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
CD40 biology T cell Immunology Germinal center BCL6 CXCR5 Cell biology 03 medical and health sciences Chemokine receptor 030104 developmental biology 0302 clinical medicine Immune system medicine.anatomical_structure medicine biology.protein Immunology and Allergy B cell 030215 immunology |
| Zdroj: | The Journal of Immunology. 201:1359-1372 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1701217 |
| Popis: | Follicular helper T (Tfh) cells are necessary for germinal center B cell maturation during primary immune responses; however, the T cells that promote humoral recall responses via memory B cells are less well defined. In this article, we characterize a human tonsillar CD4+ T cell subset with this function. These cells are similar to Tfh cells in terms of expression of the chemokine receptor CXCR5 and the inhibitory receptor PD-1, IL-21 secretion, and expression of the transcription factor BCL6; however, unlike Tfh cells that are located within the B cell follicle and germinal center, they reside at the border of the T cell zone and the B cell follicle in proximity to memory B cells, a position dictated by their unique chemokine receptor expression. They promote memory B cells to produce Abs via CD40L, IL-10, and IL-21. Our results reveal a unique extrafollicular CD4+ T cell subset in human tonsils, which specialize in promoting T cell–dependent humoral recall responses. |
| Databáze: | OpenAIRE |
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