Cytotoxic phenolic glycosides from the seeds of Senna tora
| Autor: | Tran Hong Quang, Nguyen Hoai Nam, Tran Thi Hong Hanh, Nguyen Quang Trung, Nguyen Xuan Cuong, Le Ngoc Anh, Do Hoang Anh, Chau Van Minh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Senna tora biology Chemistry Cancer Glycoside Plant Science biology.organism_classification medicine.disease Biochemistry Phytochemical medicine Ic50 values Cytotoxic T cell Cytotoxicity Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology Nuclear chemistry |
| Zdroj: | Phytochemistry Letters. 45:190-194 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2021.08.020 |
| Popis: | Phytochemical investigations of Senna tora seeds led to the isolation of fourteen phenolic glycosides, including three new compounds, namely, sennatorosides A–C (1–3). The chemical structures of the isolated compounds were confirmed by a detailed analysis of the 1D and 2D NMR, HR-ESI-QTOF mass, and ECD spectra. Among the isolated compounds, 1-[(1-( - d -glucopyranosyl)oxy-8-hydroxy-methoxynaphthalen)-6-yl]propan-2-one (11) exhibited strong cytotoxic activity against three tested cancer cell lines, SK-LU-1 (lung cancer), HepG2 (hepatoma cancer), and MCF-7 (breast cancer), with IC50 values of 8.05 ± 0.28, 9.52 ± 1.20, and 8.54 ± 0.85 μM, respectively, whereas compounds 1–4, 6–9, 12, and 14 revealed moderated or weak cytotoxicity, with IC50 values ranging from 44.59 ± 5.03–98.24 ± 2.45 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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