| Autor: |
Eleazar Hernández-Ruiz, Paula Peña-Alcántara, Uendy Pérez-Lozano, Ricardo Terrazas-Marín, María Teresa García-Lee, Luara L Arana-Luna, Paulina M Soto-Cisneros, Josué Ruiz-Contreras, Juan J Orellana-Garibay, Azucena Saavedra-González, Martha G Tavera-Rodríguez, María R Miranda-Madrazo, Patricia Estrada-Domínguez, José L López-Arroyo, Sergio José Loera-Fragoso, Fabiola Ramírez-Moreno, Adrián Javier-Morales, Flavio Rojas-Castillejos, Ana Laura Tapia-Enríquez, Lorena Nava-Villegas, Hilda Romero-Rodelo, Ma Guadalupe González-Villareal, María D Valencia-Rivas, Eugenia Patricia Paredes-Lozano, Annel Martínez-Ríos, Ana Varela-Constantino, Ma Del Carmen González-Pérez, Willy Flores-Patricio, Mario Alberto Martínez-Ramírez, Lénica A Chávez-Aguilar, Atenas Villela-Peña, Gabriela Cesarman-Maus, Irene Anaya-Cuellar, Yayra M Pichardo-Cepín, Wilfrido Herrera-Olivares, José Luis Álvarez-Vera, Ma Del Carmen González-Rubio, Jaime García Chávez, Luisa María Alcivar-Cedeño, Laura Elizabeth Merino-Pasaye, Teresa Valle-Cárdenas, Alba Morales-Hernández, Óscar Teomitzi-Sánchez, David Ávila-Castro, Faustino Leyto-Cruz, Karina Silva-Vera, Ana K Hernández-Colín, Verónica Mena-Zepeda, Juan Manuel Pérez-Zúñiga, Denisse Jocelyn Fermín-Caminero, José Antonio de la Peña-Celaya, Ramón A Bates-Martín, Shendel P Vilchis-González, Adela Segura-García, Fredy Tepepa-Flores, María Eugenia Espitia-Ríos, Martha Alvarado Ibarra, Orlando Gabriel Palma-Moreno, Sergio Tena-Cano, Mishel Rodríguez-Serna, Ana Carolina Reynoso-Pérez |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Gaceta Médica de México. 157 |
| ISSN: |
0016-3813 |
| Popis: |
Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles, and elbows). This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion-transmitted infections), or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology characterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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