Vitamin D receptor polymorphisms in overweight/obese chronic kidney disease patients undergoing hemodialysis
| Autor: | Gokhan Bagci, Ferhan Candan, Huzmeli C |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
biology TaqI business.industry Overweight medicine.disease Obesity Calcitriol receptor FokI chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein Secondary hyperparathyroidism Gene polymorphism medicine.symptom business Dyslipidemia |
| Popis: | BackgroundMany studies were carried out to investigate the relationship between single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene with obesity. However, little is known about the role of VDR gene polymorphism with obesity in hemodialysis (HD) patients. Therefore, we aimed to investigate VDR gene TaqI, ApaI and FokI SNPs in overweight/obese HD patients.MethodsSeventy one normal weight and 68 overweight/obese HD patients were included in study. PCR-RFLP method was used for genotyping. Demographic and laboratory data obtained from medical records of patients.ResultsFor all three SNPs, no significant association was found between normal and overweight/obese patients (P>0.05). Lower HDL concentrations and higher levels of triglyceride (TG) and glucose were detected in the obese/overweight patients compared to normal weight (pConclusionsOur study suggest that VDR TaqI, ApaI and FokI polymorphisms are not associated with obesity in HD patients. However, they might be increase the risk of secondary hyperparathyroidism, dyslipidemia, and hyperglycemia, which are among the most common obesity related comorbidities of chronic kidney disease. |
| Databáze: | OpenAIRE |
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