| Autor: |
E.R. Waskawic, R. N. Saunders, T. S. Burns, M. R. Stelzer |
| Rok vydání: |
1977 |
| Předmět: |
|
| Zdroj: |
VIth International Congress on Thrombosis and Haemostasis. |
| ISSN: |
2567-689X |
| DOI: |
10.1055/s-0039-1682679 |
| Popis: |
Circulating platelet aggregates (CPA) have been observed by Wu and Hoak (Lancet 2: 294, 1974) in the blood of patients with transient ischemic attacks, acute myocardial infarction and acute peripheral arterial insufficiency. We have discovered that retired breeder (RB) male rats have spontaneous CPA which respond to therapy with clinically proven antiplatelet drugs. CPA are described as the ratio of the platelet count from blood drawn into a citrate/formalin solution compared to the platelet count from blood drawn into a citrate solution. A platelet aggregate ratio (PAR) of 1.0 is indicative of the absence of CPA. The PAR of 24 virgin male rats (0.94 ± .02, S.E.M.) was significantly greater (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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