Organoid models of childhood kidney tumours

Autor:	Ariadne H. A. G. Ooms, Ronald R. de Krijger, Jarno Drost, Camilla Calandrini
Rok vydání:	2020
Předmět:	0301 basic medicine Kidney Genetic heterogeneity business.industry Urology Computational biology Phenotype 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Organoid medicine business Genetic composition
Zdroj:	Nature Reviews Urology. 17:311-313
ISSN:	1759-4820 1759-4812
DOI:	10.1038/s41585-020-0315-y
Popis:	Paediatric kidney tumours comprise many different subtypes, each being heterogeneous in their cellular as well as genetic composition. Advances in the past decade in 3D culture models create new opportunities for the generation of preclinical models capturing this phenotypic and genetic heterogeneity, potentially enabling the generation of patient-tailored therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8bddad68f9f3ee6ceda1366af377e90a https://doi.org/10.1038/s41585-020-0315-y Zobrazit plný text záznamu Full text from SpringerLink