Antibacterial Constituents fromIsodon Excisoides

Autor:	Guang-Zhou Lu, Lin-Lin Zhu, Fulin Yan, Yong-Xue Wang, Zhi-An He, Ji-Xia Zhang
Rok vydání:	2010
Předmět:	biology Chemistry Stereochemistry Chemical structure Isodon General Chemistry medicine.disease_cause biology.organism_classification Staphylococcus aureus Mic values medicine Medicinal plants Antibacterial activity Escherichia coli Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Journal of the Chinese Chemical Society. 57:256-259
ISSN:	0009-4536
DOI:	10.1002/jccs.201000039
Popis:	Two new ent-kaurane diterpenoids, taihangexcisoidesin C (1) and its acetonide, taihangexcisoidesin D (2), along with 9 known compounds were isolated from the leaves of Isodon excisoides. The structures of the new compounds were elucidated using 1D and 2D NMR spectroscopy analysis. Compounds 3-6 and 8-9 were tested for their antibacterial activity against Escherichia coli, Staphylococcus aureus, S. epidermidis and S. saprophyticus. Compound 6 showed inhibitory effects on Staphylococcus aureus, S. epidermidis and S. saprophyticus MIC values 32, 16 and 16 μg/mL, respectively. All of the compounds didn't show effects on Escherichia coli (MIC > 10 mg/mL).
Databáze:	OpenAIRE
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