The esters of 4-hydroxybenzoic acid and related compounds. Part II. Relationships between the fungistatic activity, and physical and chemical properties of the esters

Autor: G. W. K. Cavill, J. M. Vincent
Rok vydání: 1947
Předmět:
Zdroj: Journal of the Society of Chemical Industry. 66:175-182
ISSN: 1934-9971
0368-4075
Popis: The preparation of the methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec.-butyl, iso-butyl, n-amyl, iso-amyl, n-hexyl, (2-methyl)-amyl, n-heptyl and (2-ethyl)-hexyl esters of 4-hydroxybenzoic acid is described. Results are reported for the toxic action of these esters tested against three moulds: Aspergillus niger, Byssochlamys fulva and Penicillium roqueforti. The inhibitory action is described principally in terms of b (slope of the log. dosage/log. response curve) and an inhibitory index (I), being the reciprocal of the millimolar concentration required to attain a suitable level of inhibition. Where its determination has been possible (A. niger and B. fulva), b can be regarded as substantially the same for all the esters tested. The logarithm of I plotted against chain length showed a general increase from methyl to hexyl with much less, or no, increase from hexyl to heptyl. The three organisms showed, however, specific differences in their detailed reaction to successive esters. Branched esters, tested against A. niger, were close too, and usually slightly less than, the values for the corresponding normal esters. Differences are reported for the reaction of A. niger to the free acid. Experience with other compounds, particularly as constitution affects b is briefly noted. Some physico-chemical aspects of inhibition by the above compounds are discussed.
Databáze: OpenAIRE
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