Palladium-catalyzed Suzuki–Miyaura reaction of fluorinated vinyl chloride: a new approach for synthesis α and α,β-trifluoromethylstyrenes

Autor:	Dong-Huai Tu, Kun Dai, Zhong-Wen Liu, Yao-Yu Wang, Jian Lu, Zhao-Tie Liu, Yang Li, Bo Zhao, Bo Wang
Rok vydání:	2016
Předmět:	010405 organic chemistry Ligand Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Vinyl chloride 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Drug Discovery Molecule Palladium
Zdroj:	Tetrahedron. 72:5684-5690
ISSN:	0040-4020
DOI:	10.1016/j.tet.2016.07.085
Popis:	A mild and efficient palladium-catalyzed cross-coupling between fluorinated vinyl chloride and arylboronic acids is described. The use of ligand B successfully overcomes the strong electronic withdrawing of trifluoromethylated substrates and allows the efficient synthesis of a wide range of α and α,β-trifluoromethyl containing olefins. By using this method, the key intermediate for synthesis of Efavirenz can be obtained in a simple route. The efficient conversion of two freon molecules into useful α and α,β-trifluoromethyl containing olefins is a useful route in organic chemistry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b4e451a2416b58eb33317ded01aed24 https://doi.org/10.1016/j.tet.2016.07.085 Zobrazit plný text záznamu Full Text from ScienceDirect