Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists

Autor:	G.W. Antognoli, J.T. Shirley, A. Marfat, C.F. Wright, Thomas J. Carty, Frank W. Rusek, J. W. Watson, J. Delehunt, B. A. Naclerio, James F. Eggler, J.S. Pillar, Herbert Sherman, E.G. Andrews, Francis J. Sweeney, K. W. Freiert, R. Breslow, C. J. Mularski, V. L. Cohan, C J Pazoles, Lawrence S. Melvin, L.A. Rappach, John B. Cheng, David B. Damon, Jeanene E. Tickner, Judith L. Collins, P. Reiche, Hiroko Masamune, M. P. Carta, James D. Eskra, Hada William Andrew, R. J. Chambers
Rok vydání:	1995
Předmět:	LTD4 receptor Chemistry Organic Chemistry Clinical Biochemistry Drug Discovery Antagonist Pharmaceutical Science Molecular Medicine Pharmacology Receptor Molecular Biology Biochemistry First generation
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:1365-1370
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00225-i
Popis:	The development of two novel LTD 4 receptor antagonists as clinical candidates for the treatment of asthma is described. The first generation compound, CP-80,798, was found to be a balanced 5-lipoxygenase inhibitor (5-LOI)/LTD 4 antagonist (LTD 4 -A), while the second generation compound, CP-85,958, is a selective LTD 4 antagonist.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8a5fced5f481925dbd55bd727448996c https://doi.org/10.1016/0960-894x(95)00225-i Zobrazit plný text záznamu Full Text from ScienceDirect