Col2-GFP reporter mouse?A new tool to study skeletal development

Autor:	Jae Y. Cho, William A. Horton, G P Lunstrum, T. Dawn Grant
Rok vydání:	2001
Předmět:	Genetically modified mouse Optical sectioning Confocal Anatomy Biology Chondrogenesis Chondrocyte Green fluorescent protein law.invention Cell biology medicine.anatomical_structure Confocal microscopy law medicine Fluorescence microscope Genetics (clinical)
Zdroj:	American Journal of Medical Genetics. 106:251-253
ISSN:	1096-8628 0148-7299
DOI:	10.1002/ajmg.10230
Popis:	Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.
Databáze:	OpenAIRE
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