Novel apo-tirucallane triterpenoids from Walsura trifoliata

Autor:	V. Lakshma Nayak, G. Suresh, C. Venkat Rao, P. Ashok Yadav, K. Suresh Babu, K. Rajendra Prasad, Sistla Ramakrishna, M. Suri Appa Rao
Rok vydání:	2012
Předmět:	biology Chemistry Stereochemistry Organic Chemistry Ring (chemistry) biology.organism_classification Biochemistry HeLa chemistry.chemical_compound Triterpenoid Pyran Cell culture Drug Discovery Side chain Walsura trifoliata Cytotoxicity
Zdroj:	Tetrahedron Letters. 53:6241-6244
ISSN:	0040-4039
Popis:	Two structurally interesting novel apo-tirucallane triterpenoids, piscidinone A and B were isolated from the leaves and twigs of Walsura trifoliata and their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data, respectively. These novel secondary metabolites have tetracyclic ring and a new type of substituted pyran ring as a side chain, and their biosynthetic origin was proposed to be the apo-tirucallane triterpenoids. Further, compounds 1 and 2 were also evaluated for their cytotoxicity against cancer cell lines (HT-29, MCF-7, Hela, A-549, B-16, IEC-6, L-6 and PC-3), which displayed moderate activities against tested cell lines with the IC 50 values ranging from 14.33 to 50.63 μg/mL, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::89d25a008f2897afc36decfeca079c52 https://doi.org/10.1016/j.tetlet.2012.09.012 Zobrazit plný text záznamu Full Text from ScienceDirect