Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

Autor:	Elizabeth McIntosh, P. J. Owen-Lynch, I. Walker, Johanne Bentley, Stephen A. Baldwin, Anthony D. Whetton
Rok vydání:	2001
Předmět:	Glucose transporter Hematology Biology medicine.disease Philadelphia chromosome Leukemia Downregulation and upregulation Multipotent Stem Cell Cell culture hemic and lymphatic diseases medicine Cancer research Stem cell neoplasms Tyrosine kinase
Zdroj:	British Journal of Haematology. 112:212-215
ISSN:	0007-1048
DOI:	10.1046/j.1365-2141.2001.02428.x
Popis:	The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr--Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr--Abl upregulation of glucose transport was mediated by phosphatidylinositol-3-kinase. The observation that Bcr--Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.
Databáze:	OpenAIRE
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