Combination of chondroitin sulfate and hyaluronic acid increases amount of fibroblast, collagen and decreases adhesion of achilles tendon after repair
| Autor: | Tresna Angga Basunanda, Syaifullah Asmiragani, Tjuk Risantoso, Marvin Anthony Putera, Andhika Yudistira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
030222 orthopedics
medicine.medical_specialty Achilles tendon Test group business.industry Adhesion (medicine) 030229 sport sciences medicine.disease Tendon 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure Endocrinology chemistry Internal medicine Hyaluronic acid medicine Orthopedics and Sports Medicine Chondroitin sulfate Achilles tendon rupture medicine.symptom business Fibroblast |
| Zdroj: | Journal of Arthroscopy and Joint Surgery. 7:211-215 |
| ISSN: | 2214-9635 |
| DOI: | 10.1016/j.jajs.2020.06.002 |
| Popis: | Background This study was designed to evaluate the effects of chondroitin sulfate (CS) combined with hyaluronic acid (HA) on rat’s post surgically repaired achilles tendon rupture at 21 day post injury. Methods Achilles tendon of 28 male rats (Rattus Novergicus var wistar) were cut and repaired by modified Kessler technique and circular cast were applied after repair. Samples were allocated into four test group: group 1 as control had a simple tendon repair, group 2 which had hyaluronic acid administered at repair site, group 3 which had chondroitin sulfate per orally and group 4 which had combination of chondroitin sulfate per orally and hyaluronic acid administration at repair site. The rats were sacrificed at 21 days post-op and tendons were evaluated histopathologically to count the amount of fibroblast, peritendon adhesion (using microscopic Tang scoring system) and quantitative amount of collagen using colorimetric analysis. Results Treatment groups (groups 2, 3, and 4) had a significantly increased amount of fibroblast (p Conclusions These findings suggest that a combined treatment of chondroitin sulfate and hyaluronic acid could be an effective therapeutic regime in restoring the morphological properties of achilles tendon in rats model, and might provide useful knowledge for future clinical trial studies in tendon ruptures. |
| Databáze: | OpenAIRE |
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