Expression of PRAD1/cyclin D1 in plasma cell malignancy: incidence and prognostic aspects

Autor:	Akitoshi Nagasaki, Tatsuya Kimura, Takashi Sonoki, Minoru Yoshida, Hiromitsu Matsuzaki, Hiroaki Mitsuya, Fumihiko Matsuno, Noriomi Kuribayashi, Hiroyuki Hata, Naoko Harada
Rok vydání:	1999
Předmět:	Incidence (epidemiology) Hematology Plasma cell leukaemia Plasma cell Biology medicine.disease Malignancy medicine.anatomical_structure Cyclin D1 Immunopathology Gene expression Cancer research medicine Multiple myeloma
Zdroj:	British Journal of Haematology. 104:614-617
ISSN:	0007-1048
Popis:	We analysed PRAD1/cyclin D1 expression in 20 patients with plasma cell malignancy by Northern analysis. 6/17 multiple myeloma patients and 3/3 plasma cell leukaemia patients showed PRAD1/cyclin D1 expression. This incidence appeared to be higher than the expected incidence based on previous studies. Southern analysis did not show rearrangement of the bcl-1 region. Although there was no statistical difference, the PRAD1/cyclin D1 negative group showed a 1-year survival of 81.8%, 3-year survival of 45.5% and 5-year survival of 22.7%, and those for the PRAD1/cyclin D1 positive group were 63.5%, 16.9% and 16.9%, respectively. Further study is required to determine whether PRAD1/cyclin D1 expression is a prognostic factor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::88efa4ebda3a0de338ed192223823f12 https://doi.org/10.1046/j.1365-2141.1999.01204.x Zobrazit plný text záznamu Plný text