| Autor: |
Pierre Charneau, Min-Wen Ku, Philippe Souque, Fanny Moncoq, Ilta Lafosse, François Anna, Sébastien Chardenoux, David Hardy, Maryline Bourgine, Catherine Blanc, Pierre Authié, Benjamin Vesin, Jodie Lopez, Kirill Nemirov, Fabien Nevo, Françoise Guinet, Amandine Noirat, Francina Langa Vives, Laleh Majlessi |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.1101/2021.02.03.429211 |
| Popis: |
SummaryNon-integrative, non-cytopathic and non-inflammatory lentiviral vectors are particularly suitable for mucosal vaccination and recently emerge as a promising strategy to elicit sterilizing prophylaxis against SARS-CoV-2 in preclinical animal models. Here, we demonstrate that a single intranasal administration of a lentiviral vector encoding a prefusion form of SARS-CoV-2 spike glycoprotein induces full protection of respiratory tracts and totally avoids pulmonary inflammation in the susceptible hamster model. More importantly, we generated a new transgenic mouse strain, expressing the human Angiotensin Converting Enzyme 2, with unprecedent brain permissibility to SARS-CoV-2 replication and developing a lethal disease in |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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