Prevalence of Prothrombin G20210A, Factor V G1691A (Leiden), and Methylenetetrahydrofolate Reductase (MTHFR) C677T in Seven Different Populations Determined by Multiplex Allele-specific PCR
| Autor: | Debra J. Endean, Kenneth D. Friedman, Robert A. Luhm, Martin J. Hessner, Steven L. Pearson, Robert R. Montgomery |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
biology business.industry Factor V Hematology Odds ratio medicine.disease Gastroenterology Internal medicine Methylenetetrahydrofolate reductase Immunology biology.protein medicine Factor V Leiden Prothrombin G20210A Allele business Allele frequency Protein C medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 81:733-738 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0037-1614563 |
| Popis: | SummaryIndividuals belonging to six racial groups (African American, Asian Indian, Caucasian, Hispanic, Korean, Native American), and a seventh group comprised of referred patients with thrombosis were genotyped for the prothrombin G20210A mutation, the factor V G1691A (Leiden) mutation, and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation by multiplexed allele-specific PCR. The prothrombin 20210A and factor V 1691A allele frequencies in the thrombosis patients, 3.2% and 9.5%, were significantly higher than those in the random Caucasians, 1.3% and 1.8%, (p = 0.043 and p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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