Synthesis, characterization, DNA-binding, photocleavage, cytotoxicity and docking studies of Co(III) mixed ligand complexes

Autor:	Kotha Laxma Reddy, Nazar Md Gabra, C. Shobha Devi, A. Srishailam, Yata Praveen Kumar, Nishant Jain, Sirasani Satyanarayana, N. Deepika
Rok vydání:	2013
Předmět:	Stereochemistry Superoxide Singlet oxygen Intercalation (chemistry) Metals and Alloys Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Docking (molecular) Materials Chemistry Cytotoxicity Organometallic chemistry DNA
Zdroj:	Transition Metal Chemistry. 38:811-819
ISSN:	1572-901X 0340-4285
Popis:	A new ligand, (2-ethoxy-6-(1H imadazo[4,5-f][1,10]phenanthroline-2-yl)phenol) (HEPIP) and its three Co(III) complexes [Co(phen)2(HEPIP)](ClO4)3 (1), [Co(bpy)2(HEPIP)](ClO4)3 (2) and [Co(dmb)2(HEPIP)](ClO4)3 (3) have been synthesized and characterized. All three Co(III) complexes exhibited antitumor activity against four human tumor cell lines. The interaction of these complexes with calf thymus DNA was studied by absorption and emission spectroscopy, viscosity measurements and DNA cleavage assays. The DNA-binding constants of complexes 1, 2 and 3 were determined as 6.13 × 105, 4.46 × 105 and 3.72 × 105 M−1, respectively. The complexes appear to interact with DNA through intercalation. Studies on the mechanism of photocleavage indicated that both superoxide anion radical and singlet oxygen may play an important role.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8853f6011df165dd35cd5fbeb04ab9a7 https://doi.org/10.1007/s11243-013-9753-1 Zobrazit plný text záznamu Full text from SpringerLink