Preparation, quality control and stability of 99mTc-cefuroxime axetil
| Autor: | Kubra Durkan, F. Yurt Lambrecht, Perihan Ünak |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Chromatography
Chemistry Health Toxicology and Mutagenesis Thin layer Public Health Environmental and Occupational Health digestive system Pollution High-performance liquid chromatography Chloride Analytical Chemistry Nuclear Energy and Engineering Yield (chemistry) medicine Radiology Nuclear Medicine and imaging Cefuroxime Spectroscopy medicine.drug Cephalosporin Antibiotic |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 275:161-164 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-007-6999-0 |
| Popis: | Cefuroxime axetil, a cephalosporin antibiotic used to treat bacterial infections, was investigated to label with 99mTc. Radiolabeling of cefuroxime axetil was carried out by using stannous chloride method. Effects of pH and stannous chloride amount on the radiolabeling yield were investigated. The radiochemical purity of 99mTc-cefuroxime axetil was determined by thin layer radio chromatography (TLRC), electrophoresis and high performance liquid chromatography. The maximum radiolabeling yield was 98±1%. |
| Databáze: | OpenAIRE |
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