Influence of modified trandermal hormone replacement therapy, including magnesium, on bone formation markers with osteoarthrosis of spine in women
| Autor: | Stanisław Stanosz, Andrzej Puchalski, Małgorzata Stanosz |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Bone mineral
medicine.medical_specialty Ecology biology business.industry Health Toxicology and Mutagenesis medicine.medical_treatment Urology Hormone replacement therapy (menopause) Placebo Pollution Prolactin law.invention Inorganic Chemistry Lumbar Endocrinology Randomized controlled trial law Internal medicine Osteocalcin biology.protein medicine Densitometry business |
| Zdroj: | Journal of Elementology. |
| ISSN: | 1644-2296 |
| Popis: | In a randomized study 50 women, aged 51.7±2.8 years, suffering from primary osteoarthrosis (OA), were divided into two, equal groups (I, II). The women were employed in garment industry in contract work system. They were working in compulsory, mainly standing position. The women complained of backache of the lumbar region continuing for the minimum 5 years. During the study, bone mineral density (BMD) of the lumbar spine was assessed twice with the densitometry DEXA method (Lunar Corporation equipment). Before treatment, structural changes in the lumbosacral spine were revealed using a CT Simens Sonata Plus 4. One energy technique (SEQCT) was applied. Concentrations of bone-forming markers in serum were measured three times: before treatment and 3 and 12 months afterwards. The concentration of acid phosphatase in serum was assessed by the enzymatic method according to Hitachi. The concentrations of osteocalcin and procolagen were radoimmunologically assessed by means of DRG Company – sets and concentration basal prolactin (PRL) before treatment radioimmunoassy kits produced by bioMerieux. In the first stage of the treatment, the women in the first group received placebo for three months. Slow Mag B6 was administered for three months to the women in the second group. |
| Databáze: | OpenAIRE |
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