Access to (Z)-β-Substituted Enamides from N1-H-1,2,3-Triazoles

Autor:	Tao Wang, Bao-Sheng Li, Zongyuan Tang, Han Luo, Lu Qixing, Mingchuan Xu, Yi Tian
Rok vydání:	2021
Předmět:	Reaction conditions Nonmetal Chemistry Organic Chemistry Nucleophilic substitution Physical and Theoretical Chemistry Biochemistry Combinatorial chemistry Catalysis
Zdroj:	Organic Letters. 23:6293-6298
ISSN:	1523-7052 1523-7060
Popis:	A direct ring-opening/nucleophilic substitution reaction of N1-H-1,2,3-triazoles has been described. Divergent (Z)-β-halogen- or sulfonyl-substituted enamides could be stereospecifically synthesized in a tunable manner. This strategy might not only enable a new ring-opening method of N1-H-1,2,3-triazoles under nonmetal catalysis and mild reaction conditions but also offer a good opportunity to reliably access versatile (Z)-β-substituted enamides that could be used as synthetic precursors for further synthetic transformations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8724e94f111cf924da5e1417550854fa https://doi.org/10.1021/acs.orglett.1c02087 Zobrazit plný text záznamu