Association of arsenic-related AS3MT gene and antioxidant SOD2 gene expression in industrial workers occupationally exposed to arsenic
| Autor: | Nayab Khalid, Mahmood Akhtar Kayani, Zertashia Akram, Ishrat Mahjabeen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
DNA damage Health Toxicology and Mutagenesis medicine.medical_treatment SOD2 chemistry.chemical_element Physiology 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Superoxide dismutase 03 medical and health sciences medicine Arsenic 030304 developmental biology 0105 earth and related environmental sciences chemistry.chemical_classification 0303 health sciences Reactive oxygen species biology Public Health Environmental and Occupational Health chemistry Bioaccumulation biology.protein Oxidative stress |
| Zdroj: | Toxicology and Industrial Health. 36:161-169 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233720918680 |
| Popis: | Increasing anthropogenic activities related to industrialization and exposure to different toxicants increases the health hazards of industrial workers. Arsenic (As) exposure induces DNA damage and generates reactive oxygen species, which may result in many disease phenotypes. Present study explores the expression variation of As 3 methyltransferase ( AS3MT) and superoxide dismutase ( SOD2) genes in blood samples of industrial workers of different industries (brick kiln, paint, welding, pesticide, and furniture) using quantitative real-time polymerase chain reaction. A total of 250 blood samples of industrial workers were collected along with age- and gender-matched controls. Relative expression of AS3MT ( p < 0.05) and SOD2 ( p < 0.01) genes was found significantly downregulated in exposed workers compared to controls. Significant low levels of AS3MT and SOD2 gene expression were observed in workers in the paint and pesticide industry compared to other industries. Similarly, reduced expression of AS3MT ( p < 0.05) and SOD2 ( p < 0.01) was observed in smokers of industrial workers compared to smokers of the control group. Workers with >10 years of exposure had less AS3MT expression compared to workers with |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|