Characterization of Multisubstrate Processes during Membrane Digestion. (Data and hypotheses on the interactions and autoregulation of digestive and transport processes)

Autor: N. M. Timofeeva, P. De Laey, G. G. Shcherbakov, E. Ch. Tulyaganova, Iezuitova Nn, Tsvetkova Va, M. Yu. Chernyakhovskaya, Ugolev Am, Gruzdkov Aa, G. G. Koltushkina, Egorova Vv
Rok vydání: 1975
Předmět:
Zdroj: Food / Nahrung. 19:299-318
ISSN: 1521-3803
0027-769X
DOI: 10.1002/food.19750190402
Popis: The regularities of interactions of the main groups of substrates during membrane digestion, their mechanisms as well as physiological and possible clinical significance are characterized. Mono-, bi- and multisubstrate processes of the hydrolysis of proteins, fats, carbohydrates and phosphoric esters have been investigated using new experimental models. The authors show that the activity of enzymes ensuring membrane digestion is affected by various food substrates which do not serve as substrates for a given enzyme. The inhibitory and stimulating effects have been observed in the process of interactions between different groups of food substrates (for example, lipids and peptides) as well as within a single group of food substrates (for example, between different peptides, peptides and amino acids etc.). The existence of species, ontogenetic and organ characteristics of the processes of interactions at the stage of membrane hydrolysis is shown. The analysis of the mechanisms of interactions permits us to conclude that a number of enzymes accomplishing membrane digestion are allosterically regulated systems. The possible alterations in the regulatory properties of digestive enzymes in pathology are considered.
Databáze: OpenAIRE
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