Bio-important antipyrine derived Schiff bases and their transition metal complexes: Synthesis, spectroscopic characterization, antimicrobial, anthelmintic and DNA cleavage investigation
| Autor: | Sangamesh A. Patil, Ajaykumar D. Kulkarni, Shridhar Malladi, Gangadhar B. Bagihalli, M. Manjunath |
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| Rok vydání: | 2017 |
| Předmět: |
Schiff base
biology 010405 organic chemistry Stereochemistry Organic Chemistry Aspergillus niger Aspergillus flavus 010402 general chemistry medicine.disease_cause biology.organism_classification Antimicrobial 01 natural sciences 0104 chemical sciences Analytical Chemistry Inorganic Chemistry Metal chemistry.chemical_compound chemistry visual_art Octahedral molecular geometry medicine visual_art.visual_art_medium Escherichia coli Spectroscopy DNA |
| Zdroj: | Journal of Molecular Structure. 1127:314-321 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2016.07.123 |
| Popis: | Spectroscopic (IR, NMR, UV–vis, ESR, ESI-mass), magnetic and TGA studies suggests octahedral geometry for all the CoII, NiII and CuII complexes of the Schiff bases, derived from 4-aminoantipyrine and 8-formyl-7-Hydroxy-4-methylcoumarin/5-formyl-6-hydroxycoumarin, coordinated through ONO donor sites. Antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi), antifungal (Aspergillus niger, Aspergillus flavus and Cladosporium) and DNA cleavage properties of the metal complexes are investigated. The results suggested that some of the synthesized compounds are potential antimicrobials. The synthesized compounds tested for their anthelmintic activities and it was found that CoII and NiII complexes exhibited good anthelmintic properties. |
| Databáze: | OpenAIRE |
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