Aspirin revealed: A cationization strategy for detecting acetylsalicylic acid by MALDI mass spectrometry

Autor:	D. Lacey, X.K. Hu, A.V. Loboda, Robert H. Lipson, N.J. Mosey
Rok vydání:	2007
Předmět:	Aspirin Sodium Potassium Inorganic chemistry chemistry.chemical_element Protonation Condensed Matter Physics Mass spectrometry Adduct chemistry medicine Physical and Theoretical Chemistry Instrumentation Spectroscopy medicine.drug
Zdroj:	International Journal of Mass Spectrometry. 261:192-198
ISSN:	1387-3806
DOI:	10.1016/j.ijms.2006.09.022
Popis:	Experiments are described where the experimental conditions have been optimized to detect aspirin by MALDI mass spectrometry. Although protonated aspirin was not observed by MALDI, sodium and potassium aspirin adducts could be found. Significantly better signals could be obtained by using Rb and Cs salts as cationization sources. Quantum calculations were carried out to determine the structure and energetics of the Li, K, Rb, and Cs alkali—aspirin adducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::85a359287e2da30b05249c81812c5327 https://doi.org/10.1016/j.ijms.2006.09.022 Zobrazit plný text záznamu Full Text from ScienceDirect