| Autor: |
Nikolas Barkas, Philip J. Saylor, David B. Sykes, Elizabeth W. Scadden, Shenglin Mei, Anna A. Igolkina, Thomas Brouse, Taghreed Hirz, Nicolas Severe, Youmna Kfoury, Ninib Baryawno, Bryan D. Choi, Karin Gustafsson, John H. Shin, David T. Scadden, Peter V. Kharchenko |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.03.19.998658 |
| Popis: |
Bone metastases are devastating complications of cancer. They are particularly common in prostate cancer, represent incurable disease and are refractory to immunotherapy. We sought to define distinct features of the bone marrow microenvironment by analyzing single cells from prostate cancer patients’ involved bone, uninvolved bone and distant bone sites as well as bone from cancer-free, orthopedic patients and healthy individuals. Metastatic prostate cancer was associated with multifaceted immune distortion, specifically exhaustion of distinct T cell subsets, appearance of macrophages with states specific to prostate cancer bone metastases. The chemokine CCL20 was notably overexpressed by myeloid cells, as was its cognate CCR6 receptor on T cells. Disruption of the CCL20-CCR6 axis in mice with syngeneic prostate bone metastases restored T cell reactivity and significantly prolonged animal survival. Comparative high resolution analysis of prostate cancer bone metastasis shows a targeted approach for relieving local immunosuppression for therapeutic effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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