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Aim This study aimed to explore the risk factors of submucosal invasion in early colorectal cancer (ECC), so as to provide more accurate treatment strategies for ECC patients. Methods We retrospectively enrolled patients with ECC who received endoscopic or surgical treatment at the First Affiliated Hospital of Wannan Medical College, from January 2017 to December 2021. Univariate analysis and multivariate Logistic regression analysis were used to explore the risk factors of submucosal invasion in ECC. We used a receiver operating characteristic (ROC) curve to estimate the predictive value of independent risk factors for the risk of submucosal invasion in ECC. Results A total of 109 ECC patients were enrolled, among them, 46 cases (42.20%) with infiltration depth of submucosa were classified as the study group, and the remaining 63 cases without submucosal invasion were classified as the control group. Univariate analysis showed that age ≥ 65 years old, lesion diameter > 1cm, differentiation degree, lesion surface accompanied by erosion or ulceration, redness and bleeding tendency were associated with submucosal invasion of ECC (P |