Cu(II), Mn(II), Ni(II) Complexes of Mixed Amodiaquine and Paraaminobenzoic acid: Synthesis, Characterization, Antimicrobial and Toxicological Activities in Wister rats
| Autor: | Ikechukwu P. Ejidike, Abdulbasit A. Aliyu, Mercy O. Bamigboye |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
Chemistry Aspergillus niger Pharmaceutical Science Amodiaquine Antimicrobial biology.organism_classification Penicillium chrysogenum Metal Complementary and alternative medicine visual_art Octahedral molecular geometry visual_art.visual_art_medium medicine Pharmacology (medical) Agar diffusion test Candida albicans Nuclear chemistry medicine.drug |
| Zdroj: | Al-Qadisiyah Journal of Pure Science. 25:7-20 |
| ISSN: | 2411-3514 |
| DOI: | 10.29350/qjps.2020.25.4.1184 |
| Popis: | Four novel metal complexes of mixed amodiaquine and paraaminobenzoic acid have been synthesized using a standard method and confirmed by results of some physicochemical and spectroscopic techniques. Antimicrobial activities have been carried out on the complexes against some selected organisms: (antibacterial organisms: K. pneumonia, B. subtilis, E. coli, S. aureus, P. aeruginosa and S. faecalis) and (antifungal organisms: Candida albicans, Aspergillus niger and Penicillium chrysogenum) to determine their effectiveness. The complexes were evaluated for their toxicity level in wister rats. The Amodiaquine and Paraaminobenzoic acid produce complexes in ratio 1:1:1 in coordination with the metal ion. Octahedral geometry has been proposed for all the complexes. The complexes were found to be non-electrolytic in nature. The complexes were observed to be more active than their free ligands as determined by their zone of inhibition (nm). The complexes have been proved to be less toxic to the body. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|